Autophagy Regulates Endoplasmic Reticulum Homeostasis and Calcium Mobilization in T Lymphocytes
نویسندگان
چکیده
منابع مشابه
Mobilization in T Lymphocytes Reticulum Homeostasis and Calcium Autophagy Regulates Endoplasmic
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Trimeric intracellular cation channels and sarcoplasmic/endoplasmic reticulum calcium homeostasis.
Trimeric intracellular cation channels (TRIC) represents a novel class of trimeric intracellular cation channels. Two TRIC isoforms have been identified in both the human and the mouse genomes: TRIC-A, a subtype predominantly expressed in the sarcoplasmic reticulum (SR) of muscle cells, and TRIC-B, a ubiquitous subtype expressed in the endoplasmic reticulum (ER) of all tissues. Genetic ablation...
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The T lymphocyte response initiates with the recognition of MHC/peptides on antigen presenting cells by the T cell receptor (TCR). After the TCR engagement, the proximal signaling pathways are activated for downstream cellular events. Among these pathways, the calcium-signaling flux is activated through the depletion of endoplasmic reticulum (ER) calcium stores and plays pivotal roles in T cell...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2010
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.1001822